- Sophie Blanchard (b. 1778), French aeronaut. First woman to work as a professional balloonist.
- Sophie Germain (b. 1776), French mathematician, physicist and philosopher.
- Sophie Scholl (b. 1921), German anti-Nazi political activist.
- Sophie Wilson (b. 1957), British computer scientist and software engineer.
- Sophia Danenberg (1972), American mountain climber. First African-American and first black woman to reach the summit of Mount Everest (2006).
- Sophia Louisa Jex-Blake (1840-1912), British physician and feminist.
- Sofia V. Kovalevskaya (b. 1850), Russian mathematician. First woman in modern Europe to earn a doctorate in mathematics (1874) and to be appointed a professor of mathematics (1889).
Do you know of any other equally impressive people named Sophie, Sophia, Sofia, or some other variant of the name?